Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia
burgdorferi, has risen from relative obscurity to become a global public health problem and a …
burgdorferi, has risen from relative obscurity to become a global public health problem and a …
Cryo-electron tomography: the challenge of doing structural biology in situ
Electron microscopy played a key role in establishing cell biology as a discipline, by
producing fundamental insights into cellular organization and ultrastructure. Many seminal …
producing fundamental insights into cellular organization and ultrastructure. Many seminal …
The bacterial flagellar motor and its structural diversity
T Minamino, K Imada - Trends in microbiology, 2015 - cell.com
The bacterial flagellum is a reversible rotary motor powered by an electrochemical-potential
difference of specific ions across the cytoplasmic membrane. The H+-driven motor of …
difference of specific ions across the cytoplasmic membrane. The H+-driven motor of …
Visualization of the type III secretion sorting platform of Shigella flexneri
Bacterial type III secretion machines are widely used to inject virulence proteins into
eukaryotic host cells. These secretion machines are evolutionarily related to bacterial …
eukaryotic host cells. These secretion machines are evolutionarily related to bacterial …
Structural diversity of bacterial flagellar motors
The bacterial flagellum is one of nature's most amazing and well‐studied nanomachines. Its
cell‐wall‐anchored motor uses chemical energy to rotate a microns‐long filament and …
cell‐wall‐anchored motor uses chemical energy to rotate a microns‐long filament and …
Diverse high-torque bacterial flagellar motors assemble wider stator rings using a conserved protein scaffold
M Beeby, DA Ribardo, CA Brennan… - Proceedings of the …, 2016 - National Acad Sciences
Although it is known that diverse bacterial flagellar motors produce different torques, the
mechanism underlying torque variation is unknown. To understand this difference better, we …
mechanism underlying torque variation is unknown. To understand this difference better, we …
Architecture of the major component of the type III secretion system export apparatus
P Abrusci, M Vergara-Irigaray, S Johnson… - Nature structural & …, 2013 - nature.com
Type III secretion systems (T3SSs) are bacterial membrane–embedded nanomachines
designed to export specifically targeted proteins from the bacterial cytoplasm. Secretion …
designed to export specifically targeted proteins from the bacterial cytoplasm. Secretion …
Molecular architecture of chemoreceptor arrays revealed by cryoelectron tomography of Escherichia coli minicells
The chemoreceptors of Escherichia coli localize to the cell poles and form a highly ordered
array in concert with the CheA kinase and the CheW coupling factor. However, a high …
array in concert with the CheA kinase and the CheW coupling factor. However, a high …
The unique paradigm of spirochete motility and chemotaxis
Spirochete motility is enigmatic: It differs from the motility of most other bacteria in that the
entire bacterium is involved in translocation in the absence of external appendages. Using …
entire bacterium is involved in translocation in the absence of external appendages. Using …
Cellular electron cryotomography: toward structural biology in situ
Electron cryotomography (ECT) provides three-dimensional views of macromolecular
complexes inside cells in a native frozen–hydrated state. Over the last two decades, ECT …
complexes inside cells in a native frozen–hydrated state. Over the last two decades, ECT …