Current update on intrinsic and acquired colistin resistance mechanisms in bacteria
Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …
Treatment of infections caused by extended-spectrum-beta-lactamase-, AmpC-, and carbapenemase-producing Enterobacteriaceae
Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …
challenging, and some of the few active drugs are not available in many countries. For …
Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes
Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …
Seven ways to preserve the miracle of antibiotics
JG Bartlett, DN Gilbert, B Spellberg - Clinical infectious diseases, 2013 - academic.oup.com
Antibiotic resistance is a well-acknowledged crisis with no clearly defined comprehensive,
national corrective plan. We propose a number of interventions that, collectively, could make …
national corrective plan. We propose a number of interventions that, collectively, could make …
Colistin: an update on the antibiotic of the 21st century
S Biswas, JM Brunel, JC Dubus… - Expert review of anti …, 2012 - Taylor & Francis
The emergence of multidrug-resistant Gram-negative bacteria that cause nosocomial
infections is a growing problem worldwide. Colistin was first introduced in 1952 and was …
infections is a growing problem worldwide. Colistin was first introduced in 1952 and was …
Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus
In the face of diminishing therapeutic options for the treatment of infections caused by
multidrug-resistant, Gram-negative bacteria, clinicians are increasingly using colistin and …
multidrug-resistant, Gram-negative bacteria, clinicians are increasingly using colistin and …
Applications of the pharmacokinetic/pharmacodynamic (PK/PD) analysis of antimicrobial agents
The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …
High-dose, extended-interval colistin administration in critically ill patients: is this the right dosing strategy? A preliminary study
L Dalfino, F Puntillo, A Mosca, R Monno… - Clinical Infectious …, 2012 - academic.oup.com
Background. Gram-negative bacteria susceptible only to colistin (COS) are emerging causes
of severe nosocomial infections, reviving interest in the use of colistin. However, consensus …
of severe nosocomial infections, reviving interest in the use of colistin. However, consensus …
Polymyxin acute kidney injury: dosing and other strategies to reduce toxicity
Polymyxins are valuable antimicrobials for the management of multidrug-resistant Gram-
negative bacteria; however, nephrotoxicity associated with these drugs is a very common …
negative bacteria; however, nephrotoxicity associated with these drugs is a very common …
Treatment of carbapenem-resistant Klebsiella pneumoniae: the state of the art
N Petrosillo, M Giannella, R Lewis… - Expert review of anti …, 2013 - Taylor & Francis
The increasing incidence of carbapenem-resistant Klebsiella pneumoniae (CR-KP)
fundamentally alters the management of patients at risk to be colonized or infected by such …
fundamentally alters the management of patients at risk to be colonized or infected by such …