High-diversity mouse populations for complex traits
Contemporary mouse genetic reference populations are a powerful platform to discover
complex disease mechanisms. Advanced high-diversity mouse populations include the …
complex disease mechanisms. Advanced high-diversity mouse populations include the …
Pleiotropy, epistasis and the genetic architecture of quantitative traits
TFC Mackay, RRH Anholt - Nature Reviews Genetics, 2024 - nature.com
Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis
(whereby non-linear interactions between genetic polymorphisms affect the same trait) are …
(whereby non-linear interactions between genetic polymorphisms affect the same trait) are …
Genomic investigation of 18,421 lines reveals the genetic architecture of rice
Understanding how numerous quantitative trait loci (QTL) shape phenotypic variation is an
important question in genetics. To address this, we established a permanent population of …
important question in genetics. To address this, we established a permanent population of …
Genomes of the mouse collaborative cross
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
Effect of drought stress on the genetic architecture of photosynthate allocation and remobilization in pods of common bean (Phaseolus vulgaris L.), a key species for …
Background Common bean is the most important staple grain legume for direct human
consumption and nutrition. It complements major sources of carbohydrates, including …
consumption and nutrition. It complements major sources of carbohydrates, including …
Male infertility is responsible for nearly half of the extinction observed in the mouse collaborative cross
The goal of the Collaborative Cross (CC) project was to generate and distribute over 1000
independent mouse recombinant inbred strains derived from eight inbred founders. With …
independent mouse recombinant inbred strains derived from eight inbred founders. With …
The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases
Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
The long-term effects of genomic selection: 1. Response to selection, additive genetic variance, and genetic architecture
Background Genomic selection has revolutionized genetic improvement in animals and
plants, but little is known about its long-term effects. Here, we investigated the long-term …
plants, but little is known about its long-term effects. Here, we investigated the long-term …
Epistasis: searching for interacting genetic variants using crosses
IM Ehrenreich - Genetics, 2017 - academic.oup.com
Within quantitative genetics, the term “epistasis” is used to broadly describe situations in
which combinations of genetic variants show nonadditive phenotypic effects (Phillips 1998 …
which combinations of genetic variants show nonadditive phenotypic effects (Phillips 1998 …
High-throughput sleep phenoty** produces robust and heritable traits in Diversity Outbred mice and their founder strains
Abstract Study Objectives This study describes high-throughput phenoty** strategies for
sleep and circadian behavior in mice, including examinations of robustness, reliability, and …
sleep and circadian behavior in mice, including examinations of robustness, reliability, and …