The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

Neutrophils are part of a family of granulocytes that, together with eosinophils and basophils,
play an essential role in innate immunity. Neutrophils are the most abundant circulating …

Canonical Wnt signaling critically regulates cell fate and proliferation in development and
disease. Nuclear localization of β-catenin is indispensable for canonical Wnt signaling; …

Short chain fatty acids (SCFAs) have recently attracted attention as potential mediators of the
effects of gut microbiota on intestinal inflammation. Some of these effects have been …

Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated
process that involves gradient sensing, motility, and polarity. Most of our understanding of …

A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here
we summarize recent findings on the initial steps in chemokine receptor–induced signal …

The directional migration of neutrophils towards inflammatory mediators, such as
chemokines and cannabinoids, occurs via the activation of seven transmembrane G protein …

Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …

Summary While the small GTPase Rac1 and its effectors are well-established mediators of
mitogenic and motile signaling by tyrosine kinase receptors and have been implicated in …

Rac GTPases, small G-proteins widely implicated in tumorigenesis and metastasis,
transduce signals from tyrosine-kinase, G-protein-coupled receptors (GPCRs), and integrins …