Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

BACKGROUND Primary dysmenorrhea, or painful menstruation in the absence of pelvic
pathology, is a common, and often debilitating, gynecological condition that affects between …

Chronic pain is one of the most prevalent health problems in our modern world, with millions
of people debilitated by conditions such as back pain, headache and arthritis. To address …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Rumination is a form of thought characterized by repetitive focus on discomforting emotions
or stimuli. In chronic pain disorders, rumination can impede treatment efficacy. The brain …

Pain is a complex sensory and emotional experience that is heavily influenced by prior
experience and expectations of pain. Before the development of noninvasive human brain …

The perception of pain is subject to powerful influences. Understanding how these are
mediated at a neuroanatomical and neurobiological level provides us with valuable …

Pain and pleasure are powerful motivators of behaviour and have historically been
considered opposites. Emerging evidence from the pain and reward research fields points to …

The state of our understanding of the interaction between pain and the brain is undergoing a
veritable revolution, with new surprising observations accumulating at a fast pace. A cursory …

The idea that pain can lead to feelings of frustration, worry, anxiety and depression seems
obvious, particularly if it is of a chronic nature. However, there is also evidence for the …