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Animal models of obesity and diabetes mellitus
More than one-third of the worldwide population is overweight or obese and therefore at risk
of develo** type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
of develo** type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
Sex hormones, intestinal inflammation, and the gut microbiome: major influencers of the sexual dimorphisms in obesity
Obesity is defined as the excessive accumulation of body fat and is associated with an
increased risk of develo** major health problems such as cardiovascular disease …
increased risk of develo** major health problems such as cardiovascular disease …
FGF21–Sirtuin 3 Axis confers the protective effects of exercise against diabetic cardiomyopathy by governing mitochondrial integrity
Background: Exercise is an effective nonpharmacological strategy to alleviate diabetic
cardiomyopathy (DCM) through poorly defined mechanisms. FGF21 (fibroblast growth factor …
cardiomyopathy (DCM) through poorly defined mechanisms. FGF21 (fibroblast growth factor …
TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer
High CD8+ T cell infiltration in colorectal cancer (CRC) should suggest a favorable
prognosis and a satisfactory response to immunotherapy; however, the vast majority of …
prognosis and a satisfactory response to immunotherapy; however, the vast majority of …
High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes
Mitochondria are fascinating structures of the cellular compartments that generate energy to
run the cells. However, inherent disorders of mitochondria due to diabetes can cause major …
run the cells. However, inherent disorders of mitochondria due to diabetes can cause major …
β-cell–mimetic designer cells provide closed-loop glycemic control
Chronically deregulated blood-glucose concentrations in diabetes mellitus result from a loss
of pancreatic insulin-producing β cells (type 1 diabetes, T1D) or from impaired insulin …
of pancreatic insulin-producing β cells (type 1 diabetes, T1D) or from impaired insulin …
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes
Both obesity and sarcopenia are frequently associated in ageing, and together may promote
the progression of related conditions such as diabetes and frailty. However, little is known …
the progression of related conditions such as diabetes and frailty. However, little is known …
Mouse models of diabetes, obesity and related kidney disease
Multiple rodent models have been used to study diabetic kidney disease (DKD). The
purpose of the present study was to compare models of diabetes and obesity-induced …
purpose of the present study was to compare models of diabetes and obesity-induced …
The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes
D Liu, R **ng, Q Zhang, X Tian, Y Qi, H Song… - … & molecular medicine, 2023 - nature.com
Autophagy plays an important role in the development of diabetic cardiomyopathy. Cellular
repressor of E1A-stimulated genes 1 (CREG1) is an important myocardial protective factor …
repressor of E1A-stimulated genes 1 (CREG1) is an important myocardial protective factor …
Sargassum fusiforme fucoidan modifies gut microbiota and intestinal metabolites during alleviation of hyperglycemia in type 2 diabetic mice
Q Wu, S Wu, Y Cheng, Z Zhang, G Mao, S Li, Y Yang… - Food & Function, 2021 - pubs.rsc.org
Type 2 diabetic mellitus (T2DM) is a complicated metabolic disorder that is now considered
as a major global public health problem. Fucoidan exhibits diverse biological activities …
as a major global public health problem. Fucoidan exhibits diverse biological activities …