Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

J Deprez, G Lajoinie, Y Engelen, SC De Smedt… - Advanced drug delivery …, 2021 - Elsevier
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …

Bursting microbubbles: How nanobubble contrast agents can enable the future of medical ultrasound molecular imaging and image-guided therapy

AA Exner, MC Kolios - Current opinion in colloid & interface science, 2021 - Elsevier
The field of medical ultrasound has undergone a significant evolution since the development
of microbubbles as contrast agents. However, because of their size, microbubbles remain in …

Probing the pressure dependence of sound speed and attenuation in bubbly media: Experimental observations, a theoretical model and numerical calculations

AJ Sojahrood, Q Li, H Haghi, R Karshafian… - Ultrasonics …, 2023 - Elsevier
The problem of attenuation and sound speed of bubbly media has remained partially
unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation …

Toward precisely controllable acoustic response of shell-stabilized nanobubbles: High yield and narrow dispersity

A Jafari Sojahrood, AC de Leon, R Lee, M Cooley… - ACS …, 2021 - ACS Publications
Understanding the pressure dependence of the nonlinear behavior of ultrasonically excited
phospholipid-stabilized nanobubbles (NBs) is important for optimizing ultrasound exposure …

Efficient ultrasound-mediated drug delivery to orthotopic liver tumors–direct comparison of doxorubicin-loaded nanobubbles and microbubbles

P Nittayacharn, E Abenojar, MB Cooley… - Journal of Controlled …, 2024 - Elsevier
Liver metastasis is a major obstacle in treating aggressive cancers, and current therapeutic
options often prove insufficient. To overcome these challenges, there has been growing …

[HTML][HTML] Bubble-based drug delivery systems: Next-generation diagnosis to therapy

M Kancheva, L Aronson, T Pattilachan, F Sautto… - Journal of Functional …, 2023 - mdpi.com
Current radiologic and medication administration is systematic and has widespread side
effects; however, the administration of microbubbles and nanobubbles (MNBs) has the …

[HTML][HTML] Influence of the liquid ionic strength on the resonance frequency and shell parameters of lipid-coated microbubbles

AJ Sojahrood, C Yang, C Counil, P Nittayacharn… - Journal of Colloid and …, 2024 - Elsevier
The correct measurement of the resonance frequency and shell properties of coated
microbubbles (MBs) is essential in understanding and optimizing their response to …

High throughput microfluidic nanobubble generation by microporous membrane integration and controlled bubble shrinkage

AA Paknahad, IO Zalloum, R Karshafian… - Journal of Colloid and …, 2024 - Elsevier
Microfluidics has recently been proposed as a viable method for producing bulk
nanobubbles for use in various applications. The portability, compact size, and capacity to …

Super-resolved microbubble localization in single-channel ultrasound RF signals using deep learning

N Blanken, JM Wolterink, H Delingette… - IEEE transactions on …, 2022 - ieeexplore.ieee.org
Recently, super-resolution ultrasound imaging with ultrasound localization microscopy
(ULM) has received much attention. However, ULM relies on low concentrations of …

Buckling of lipidic ultrasound contrast agents under quasi-static load

G Chabouh, B van Elburg… - … of the Royal …, 2023 - royalsocietypublishing.org
Collapse of lipidic ultrasound contrast agents under high-frequency compressive load has
been historically interpreted by the vanishing of surface tension. By contrast, buckling of …