Multiple Sclerosis (MS) is considered the most frequent inflammatory demyelinating disease
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …

To maintain the homeostatic environment required for proper function of central nervous
system (CNS) neurons the endothelial cells of CNS microvessels tightly regulate the …

Emerging clinical and experimental evidence demonstrates that neuroinflammation plays an
important role in cognitive impairment associated with neuropathic pain. However, how …

The blood–brain barrier (BBB) is an important physiologic barrier that separates CNS from
soluble inflammatory mediators and effector immune cells from peripheral circulation. The …

The human immunodeficiency virus (HIV) enters the central nervous system (CNS) within a
few days after primary infection, establishing viral reservoirs that persist even with combined …

Approximately 37 million people worldwide are infected with human immunodeficiency virus
(HIV). One highly significant complication of HIV infection is the development of HIV …

HIV infection is an ongoing global health issue, despite increased access to antiretroviral
therapy (ART). People living with HIV (PLWH) who are virally suppressed through ART still …

The gastrointestinal microbiome has emerged as a key player in regulating brain and
behaviour. This has led to the strategy of targeting the gut microbiota to ameliorate disorders …

Peritonitis and peritonitis-associated sepsis are characterized by an increased formation of
platelet–neutrophil complexes (PNCs), which contribute to an excessive migration of …

The CXCL12 system is central to the development of many organs and is further crucially
engaged in pathophysiological processes underlying cancer, inflammation, and …