The thymus is an organ that is critically important to the immune system, which serves as the
body's defense mechanism, providing surveillance and protection against diverse …

Bridging the gap between findings in preclinical 2D cell culture models and in vivo tissue
cultures has been challenging; the simple microenvironment of 2D monolayer culture …

Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but few
have been identified thus far. We therefore developed a proteogenomic approach to enable …

T cell development and selection are coordinated in the thymus by a specialized niche of
diverse stromal populations,–. Although much progress has been made over the years in …

The thymus is responsible for generating a diverse yet self-tolerant pool of T cells. Although
the thymic medulla consists mostly of develo** and mature AIRE+ epithelial cells, recent …

The generation of a functional T cell repertoire in the thymus is mainly orchestrated by
thymic epithelial cells (TECs), which provide develo** T cells with cues for their …

T cell development in the thymus is essential for cellular immunity and depends on the
organotypic thymic epithelial microenvironment. In comparison with other organs, the size …

Hematopoietic humanized (hu) mice are powerful tools for modeling the action of human
immune system and are widely used for preclinical studies and drug discovery. However …

Thymus development is critical to the adaptive immune system, yet a comprehensive
transcriptional framework capturing thymus organogenesis at single-cell resolution is still …

Invariant natural killer T (iNKT) cells are a group of innate-like T lymphocytes that recognize
lipid antigens. They are supposed to be tissue resident and important for systemic and local …