Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for
cells to probe their environment. Consequently, filopodia have an important role in cell …

Cells receive extracellular stimuli in various ways: in the form of soluble molecules (growth
factors, cytokines and hormones) that interact with cell-surface receptors; from adhesive …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

BAR domain proteins contribute to membrane deformation in diverse cellular processes.
The inverted-BAR (I-BAR) protein IRSp53, for instance, is found on the inner leaflet of the …

Actin remodeling is at the heart of the response of cells to external or internal stimuli,
allowing a variety of membrane protrusions to form. Fifteen years ago, tunneling nanotubes …

Spermiation is the process by which mature spermatids are released from Sertoli cells into
the seminiferous tubule lumen prior to their passage to the epididymis. It takes place over …

Actin filament assembly typically occurs in association with cellular membranes. A large
number of proteins sit at the interface between actin networks and membranes, playing …

The invasiveness of cells is correlated with the presence of dynamic actin-rich membrane
structures called invadopodia, which are membrane protrusions that are associated with …

Elements of the cytoskeleton interact intimately and communicate bidirectionally with cellular
membranes. Such interactions are critical for a host of cellular processes. Here we focus on …