Fibroblast growth factor receptors as treatment targets in clinical oncology
M Katoh - Nature reviews Clinical oncology, 2019 - nature.com
FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …
Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment
G Liu, T Chen, Z Ding, Y Wang, Y Wei, X Wei - Cell proliferation, 2021 - Wiley Online Library
The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …
The landscape of genomic alterations across childhood cancers
Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for the
identification of therapeutic targets, clinical research, and advancing patient care. Because …
identification of therapeutic targets, clinical research, and advancing patient care. Because …
[HTML][HTML] FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis
M Katoh - International journal of molecular medicine, 2016 - spandidos-publications.com
Abstract Fibroblast growth factor (FGF) 2, FGF4, FGF7 and FGF20 are representative
paracrine FGFs binding to heparan-sulfate proteoglycan and fibroblast growth factor …
paracrine FGFs binding to heparan-sulfate proteoglycan and fibroblast growth factor …
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …
action of a large repertoire of membrane proteins, especially ion channels. Unique …
Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies
Abstract Schlafen 11 (SLFN11) sensitizes cells to a broad range of anti-cancer drugs
including platinum derivatives (cisplatin and carboplatin), inhibitors of topoisomerases …
including platinum derivatives (cisplatin and carboplatin), inhibitors of topoisomerases …
Therapeutics targeting FGF signaling network in human diseases
M Katoh - Trends in pharmacological sciences, 2016 - cell.com
Fibroblast growth factor (FGF) signaling through its receptors, FGFR1, FGFR2, FGFR3, or
FGFR4, regulates cell fate, angiogenesis, immunity, and metabolism. Dysregulated FGF …
FGFR4, regulates cell fate, angiogenesis, immunity, and metabolism. Dysregulated FGF …
Future applications of FGF/FGFR inhibitors in cancer
Introduction: Deregulation of the fibroblast growth factor (FGF)/FGF receptor (FGFR) network
occurs frequently in tumors due to gene amplification, activating mutations, and oncogenic …
occurs frequently in tumors due to gene amplification, activating mutations, and oncogenic …
A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance
M Dietel, K Jöhrens, MV Laffert, M Hummel… - Cancer gene …, 2015 - nature.com
In April 2013 our group published a review on predictive molecular pathology in this journal.
Although only 2 years have passed many new facts and stimulating developments have …
Although only 2 years have passed many new facts and stimulating developments have …