Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …
either promoters or inhibitors of cell death. The functional interplay and balance between the …
BCL-2 family proteins: changing partners in the dance towards death
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …
The concept of intrinsic versus extrinsic apoptosis
L Lossi - Biochemical Journal, 2022 - portlandpress.com
Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …
Mechanisms of action of Bcl-2 family proteins
The Bcl-2 family of proteins controls a critical step in commitment to apoptosis by regulating
permeabilization of the mitochondrial outer membrane (MOM). The family is divided into …
permeabilization of the mitochondrial outer membrane (MOM). The family is divided into …
Multiple functions of BCL-2 family proteins
JM Hardwick, L Soane - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …
family of interacting partners includes inhibitors and inducers of cell death. Together they …
Control of mitochondrial apoptosis by the Bcl-2 family
JK Brunelle, A Letai - Journal of cell science, 2009 - journals.biologists.com
Programmed cell death, or apoptosis, is important for the development and homeostasis of
tissues. Too little cell death can result in autoimmune diseases or cancer, whereas …
tissues. Too little cell death can result in autoimmune diseases or cancer, whereas …
Lemongrass essential oil components with antimicrobial and anticancer activities
The prominent cultivation of lemongrass (Cymbopogon spp.) relies on the pharmacological
incentives of its essential oil. Lemongrass essential oil (LEO) carries a significant amount of …
incentives of its essential oil. Lemongrass essential oil (LEO) carries a significant amount of …
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
PE Czabotar, D Westphal, G Dewson, S Ma… - Cell, 2013 - cell.com
In stressed cells, apoptosis ensues when Bcl-2 family members Bax or Bak oligomerize and
permeabilize the mitochondrial outer membrane. Certain BH3-only relatives can directly …
permeabilize the mitochondrial outer membrane. Certain BH3-only relatives can directly …
Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis
D Westphal, RM Kluck, G Dewson - Cell Death & Differentiation, 2014 - nature.com
The central role of the Bcl-2 family in regulating apoptotic cell death was first identified in the
1980s. Since then, significant in-roads have been made in identifying the multiple members …
1980s. Since then, significant in-roads have been made in identifying the multiple members …
The role of cyclooxygenase‐2 in cell proliferation and cell death in human malignancies
It is well admitted that the link between chronic inflammation and cancer involves cytokines
and mediators of inflammatory pathways, which act during the different steps of …
and mediators of inflammatory pathways, which act during the different steps of …