When the production of reactive oxygen species (ROS) is overloaded surpassing the
capacity of the reductive rheostat, mammalian cells undergo a series of oxidative damage …

Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the
largest organ in the human body and it plays a crucial role in the regulation of the body's …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Skin aging is characterized by changes in its structural, cellular, and molecular components
in both the epidermis and dermis. Dermal aging is distinguished by reduced dermal …

Oxidative stress (OS) is primarily caused by the formation of free radicals and reactive
oxygen species; it is considered as one of the prominent factors in slowing down and …

Skin areas exposed to ultraviolet radiation (UV) from sunlight are more prone to photoaging
than unexposed areas evidenced by several signs which include skin dryness, irregular …

The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …

Somatic cells accumulate genomic alterations with age; however, our understanding of
mitochondrial DNA (mtDNA) mosaicism remains limited. Here we investigated the genomes …

The relentless pursuit of effective strategies against skin aging has led to significant interest
in the role of bioactive factors, particularly secondary metabolites from natural sources. The …