Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A)
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …

Centromeres are scaffolds for the assembly of kinetochores that ensure chromosome
segregation during cell division. How vertebrate centromeres obtain a three-dimensional …

Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have
come to be defined as chromatin structures that establish the assembly site for the complex …

Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

Centromeres are specialized chromosome loci that seed the kinetochore, a large protein
complex that effects chromosome segregation. A 16-subunit complex, the constitutive …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Chromosome segregation during mitosis requires assembly of the kinetochore complex at
the centromere. Kinetochore assembly depends on specific recognition of the histone …