The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been
difficult in part because a simple method to simultaneously quantify their abundance and …

Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …

Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate
cancer survival and progression, but the underlying mechanisms are poorly understood …

Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …

Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …

The tyrosine kinase inhibitor lenvatinib is a first-line drug for treating patients with advanced
hepatocellular carcinoma (HCC). However, its efficacy is severely hampered by drug …