The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Abstract Machine learning is increasingly recognized as a promising technology in the
biological, biomedical, and behavioral sciences. There can be no argument that this …

To investigate how cells sense stiffness in settings structurally similar to native extracellular
matrices, we designed a synthetic fibrous material with tunable mechanics and user-defined …

Cell biology heavily relies on the behavior of fibrillar structures, such as the cytoskeleton, yet
the analysis of their behavior in tissues often remains qualitative. Image analysis tools have …

Stem cells hold great promise for widespread biomedical applications, for which stem cell
fate needs to be well tailored. Besides biochemical cues, accumulating evidence has …

Cells can sense and respond to mechanical signals over relatively long distances across
fibrous extracellular matrices. Recently proposed models suggest that long-range force …

Significance: Chronic wounds, such as diabetic foot ulcers, venous stasis ulcers, and
pressure ulcers affect millions of Americans each year, and disproportionately afflict our …

Contractile cells can reorganize fibrous extracellular matrices and form dense tracts of fibers
between neighboring cells. These tracts guide the development of tubular tissue structures …

Contractile forces exerted on the surrounding extracellular matrix (ECM) lead to the
alignment and stretching of constituent fibers within the vicinity of cells. As a consequence …

Integration of data across spatial, temporal, and functional scales is a primary focus of
biomedical engineering efforts. The advent of powerful computing platforms, coupled with …