Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

We performed comprehensive proteogenomic characterization of small cell lung cancer
(SCLC) using paired tumors and adjacent lung tissues from 112 treatment-naive patients …

Cryptic promoters within transposable elements (TEs) can be transcriptionally reactivated in
tumors to create new TE-chimeric transcripts, which can produce immunogenic antigens. We …

Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-
negative breast cancer (TNBC). The extracellular matrix (ECM) contributes to immune …

The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …

Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Mass-spectrometry-based proteomic data on human tumors—combined with corresponding
multi-omics data—present opportunities for systematic and pan-cancer proteogenomic …

Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …

Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …