The metabolic roots of senescence: mechanisms and opportunities for intervention

CD Wiley, J Campisi - Nature Metabolism, 2021 - nature.com
Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

Neuroprotective effect of antioxidants in the brain

KH Lee, M Cha, BH Lee - International journal of molecular sciences, 2020 - mdpi.com
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

J Olechnowicz, A Tinkov, A Skalny… - The journal of …, 2018 - Springer
A number of studies have reported that zinc plays a substantial role in the development of
metabolic syndrome, taking part in the regulation of cytokine expression, suppressing …

Role of zinc in immune system and anti-cancer defense mechanisms

D Skrajnowska, B Bobrowska-Korczak - Nutrients, 2019 - mdpi.com
The human body cannot store zinc reserves, so a deficiency can arise relatively quickly, eg,
through an improper diet. Severe zinc deficiency is rare, but mild deficiencies are common …

[HTML][HTML] The role of metallothionein in oxidative stress

B Ruttkay-Nedecky, L Nejdl, J Gumulec, O Zitka… - International journal of …, 2013 - mdpi.com
Free radicals are chemical particles containing one or more unpaired electrons, which may
be part of the molecule. They cause the molecule to become highly reactive. The free …

[HTML][HTML] Zinc and oxidative stress: current mechanisms

DN Marreiro, KJC Cruz, JBS Morais, JB Beserra… - Antioxidants, 2017 - mdpi.com
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules,
contributing to the oxidative damage of cells and tissues. This consequently contributes to …

Atomic structure of the entire mammalian mitochondrial complex I

K Fiedorczuk, JA Letts, G Degliesposti, K Kaszuba… - Nature, 2016 - nature.com
Mitochondrial complex I (also known as NADH: ubiquinone oxidoreductase) contributes to
cellular energy production by transferring electrons from NADH to ubiquinone coupled to …

Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases

S Choi, X Liu, Z Pan - Acta Pharmacologica Sinica, 2018 - nature.com
Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-
inflammatory functions. The association between zinc deficiency and the development of …

Exploring the potential function of trace elements in human health: a therapeutic perspective

MR Islam, S Akash, MH Jony, MN Alam… - Molecular and Cellular …, 2023 - Springer
A trace element, known as a minor element, is a chemical element whose concentration is
very low. They are divided into essential and non-essential classes. Numerous physiological …

[HTML][HTML] Health position paper and redox perspectives-disease burden by transportation noise

M Sørensen, G Pershagen, JD Thacher, T Lanki… - Redox Biology, 2024 - Elsevier
Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization
concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart …