Inflammatory bowel disease (IBD) is a chronic and life‐threating inflammatory disease of
gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis …

Macrophages are strategically located throughout the body tissues, where they ingest and
process foreign materials, dead cells and debris and recruit additional macrophages in …

Resolution of inflammation is a coordinated and active process aimed at restoration of tissue
integrity and function. This review integrates the key molecular and cellular mechanisms of …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …

Suppression of immune responses is necessary to limit damage to host tissue during
inflammation, but it can be detrimental in specific immune responses, such as sepsis and …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that
expand during cancer, inflammation and infection, and that have a remarkable ability to …

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …

A large body of evidence indicates that chronic inflammation is one of several key risk
factors for cancer initiation, progression, and metastasis. However, the underlying …

Many cancer immunotherapies developed in experimental animals have been tested in
clinical trials. Although some have shown modest clinical effects, most have not been …

Despite the fact that inflammatory bowel disease (IBD) has still no recognised therapy,
treatments which have proven at least mildly successful in improving IBD symptoms include …