In-cell structural biology by NMR: the benefits of the atomic scale

FX Theillet - Chemical reviews, 2022 - ACS Publications
In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Paramagnetic chemical probes for studying biological macromolecules

Q Miao, C Nitsche, H Orton, M Overhand… - Chemical …, 2022 - ACS Publications
Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …

Iron oxide nanoparticles as positive T1 contrast agents for low-field magnetic resonance imaging at 64 mT

SD Oberdick, KV Jordanova, JT Lundstrom, G Parigi… - Scientific Reports, 2023 - nature.com
We have investigated the efficacy of superparamagnetic iron oxide nanoparticles (SPIONs)
as positive T1 contrast agents for low-field magnetic resonance imaging (MRI) at 64 …

Pseudocontact shifts in biomolecular NMR spectroscopy

T Müntener, D Joss, D Häussinger… - Chemical Reviews, 2022 - ACS Publications
Paramagnetic centers in biomolecules, such as specific metal ions that are bound to a
protein, affect the nuclei in their surrounding in various ways. One of these effects is the …

Rare earth elements (REE) in biology and medicine

P Ascenzi, M Bettinelli, A Boffi, M Botta… - … Lincei. Scienze Fisiche …, 2020 - Springer
This survey reports on topics that were presented at the workshop on “Challenges with Rare
Earth Elements. The Periodic Table at work for new Science & Technology” hold at the …

13C Direct Detected NMR for Challenging Systems

IC Felli, R Pierattelli - Chemical reviews, 2022 - ACS Publications
Thanks to recent improvements in NMR spectrometer hardware and pulse sequence design,
modern 13C NMR has become a useful tool for biomolecular applications. The complete …

A dysprosium single molecule magnet outperforming current pseudocontact shift agents

FS Santana, M Perfetti, M Briganti, F Sacco… - Chemical …, 2022 - pubs.rsc.org
A common criterion for designing performant single molecule magnets and pseudocontact
shift tags is a large magnetic anisotropy. In this article we present a dysprosium complex …

Paramagnetic NMR in drug discovery

CA Softley, MJ Bostock, GM Popowicz… - Journal of Biomolecular …, 2020 - Springer
The presence of an unpaired electron in paramagnetic molecules generates significant
effects in NMR spectra, which can be exploited to provide restraints complementary to those …

Two-electron two-nucleus effective Hamiltonian and the spin diffusion barrier

G von Witte, S Kozerke, M Ernst - Science Advances, 2025 - science.org
Dynamic nuclear polarization (DNP) and emerging quantum technologies rely on the spin
transfer in electron-nuclear hybrid quantum systems. Spin transfers might be suppressed by …

[HTML][HTML] Solvent paramagnetic relaxation enhancement as a versatile method for studying structure and dynamics of biomolecular systems

AJ Lenard, FAA Mulder, T Madl - Progress in Nuclear Magnetic Resonance …, 2022 - Elsevier
Solvent paramagnetic relaxation enhancement (sPRE) is a versatile nuclear magnetic
resonance (NMR)-based method that allows characterization of the structure and dynamics …