Cellular and molecular mechanisms of asthma and COPD

PJ Barnes - Clinical science, 2017 - portlandpress.com
Asthma and chronic obstructive pulmonary disease (COPD) both cause airway obstruction
and are associated with chronic inflammation of the airways. However, the nature and sites …

Progress in the mechanism and targeted drug therapy for COPD

C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …

Cross-talk between alveolar macrophages and lung epithelial cells is essential to maintain lung homeostasis

EY Bissonnette, JF Lauzon-Joset, JS Debley… - Frontiers in …, 2020 - frontiersin.org
The main function of the lung is to perform gas exchange while maintaining lung
homeostasis despite environmental pathogenic and non-pathogenic elements contained in …

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

PJ Barnes, SD Shapiro… - European Respiratory …, 2003 - publications.ersnet.org
Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …

Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids

D Czock, F Keller, FM Rasche, U Häussler - Clinical pharmacokinetics, 2005 - Springer
Glucocorticoids have pleiotropic effects that are used to treat diverse diseases such as
asthma, rheumatoid arthritis, systemic lupus erythematosus and acute kidney transplant …

Mechanistic links between COPD and lung cancer

AMG Houghton - Nature Reviews Cancer, 2013 - nature.com
Numerous epidemiological studies have consistently linked the presence of chronic
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …

NRF2 activation reprograms defects in oxidative metabolism to restore macrophage function in chronic obstructive pulmonary disease

EM Ryan, P Sadiku, P Coelho, ER Watts… - American journal of …, 2023 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is a disease characterized by
persistent airway inflammation and disordered macrophage function. The extent to which …

Outcomes for COPD pharmacological trials: from lung function to biomarkers

M Cazzola, W MacNee, FJ Martinez… - European …, 2008 - publications.ersnet.org
The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …

Mediators of chronic obstructive pulmonary disease

PJ Barnes - Pharmacological reviews, 2004 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …

Inflammation and cellular immune responses in abdominal aortic aneurysms

K Shimizu, RN Mitchell, P Libby - Arteriosclerosis, thrombosis, and …, 2006 - ahajournals.org
Expansion and rupture of abdominal aortic aneurysms (AAA) result in high morbidity and
mortality rates. Like stenotic atherosclerotic lesions, AAA accumulate inflammatory cells, but …