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Cellular and molecular mechanisms of asthma and COPD
PJ Barnes - Clinical science, 2017 - portlandpress.com
Asthma and chronic obstructive pulmonary disease (COPD) both cause airway obstruction
and are associated with chronic inflammation of the airways. However, the nature and sites …
and are associated with chronic inflammation of the airways. However, the nature and sites …
Progress in the mechanism and targeted drug therapy for COPD
C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
Cross-talk between alveolar macrophages and lung epithelial cells is essential to maintain lung homeostasis
EY Bissonnette, JF Lauzon-Joset, JS Debley… - Frontiers in …, 2020 - frontiersin.org
The main function of the lung is to perform gas exchange while maintaining lung
homeostasis despite environmental pathogenic and non-pathogenic elements contained in …
homeostasis despite environmental pathogenic and non-pathogenic elements contained in …
Chronic obstructive pulmonary disease: molecular and cellularmechanisms
Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …
only recently been extensively explored from a cellular and molecular perspective. There is …
Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids
D Czock, F Keller, FM Rasche, U Häussler - Clinical pharmacokinetics, 2005 - Springer
Glucocorticoids have pleiotropic effects that are used to treat diverse diseases such as
asthma, rheumatoid arthritis, systemic lupus erythematosus and acute kidney transplant …
asthma, rheumatoid arthritis, systemic lupus erythematosus and acute kidney transplant …
Mechanistic links between COPD and lung cancer
AMG Houghton - Nature Reviews Cancer, 2013 - nature.com
Numerous epidemiological studies have consistently linked the presence of chronic
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …
NRF2 activation reprograms defects in oxidative metabolism to restore macrophage function in chronic obstructive pulmonary disease
EM Ryan, P Sadiku, P Coelho, ER Watts… - American journal of …, 2023 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is a disease characterized by
persistent airway inflammation and disordered macrophage function. The extent to which …
persistent airway inflammation and disordered macrophage function. The extent to which …
Outcomes for COPD pharmacological trials: from lung function to biomarkers
M Cazzola, W MacNee, FJ Martinez… - European …, 2008 - publications.ersnet.org
The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …
Mediators of chronic obstructive pulmonary disease
PJ Barnes - Pharmacological reviews, 2004 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …
problem that is now a leading cause of death. COPD is associated with a chronic …
Inflammation and cellular immune responses in abdominal aortic aneurysms
K Shimizu, RN Mitchell, P Libby - Arteriosclerosis, thrombosis, and …, 2006 - ahajournals.org
Expansion and rupture of abdominal aortic aneurysms (AAA) result in high morbidity and
mortality rates. Like stenotic atherosclerotic lesions, AAA accumulate inflammatory cells, but …
mortality rates. Like stenotic atherosclerotic lesions, AAA accumulate inflammatory cells, but …