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Effects of extracellular matrix viscoelasticity on cellular behaviour
Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …
Role of extracellular matrix in development and cancer progression
The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …
Osteocytes: master orchestrators of bone
Osteocytes comprise the overwhelming majority of cells in bone and are its only true
“permanent” resident cell population. In recent years, conceptual and technological …
“permanent” resident cell population. In recent years, conceptual and technological …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
[HTML][HTML] Production of food-grade microcarriers based on by-products from the food industry to facilitate the expansion of bovine skeletal muscle satellite cells for …
A major challenge for successful cultured meat production is the requirement for large
quantities of skeletal muscle satellite cells (MuSCs). Commercial microcarriers (MCs), such …
quantities of skeletal muscle satellite cells (MuSCs). Commercial microcarriers (MCs), such …
The soft-and hard-heartedness of cardiac fibroblasts: mechanotransduction signaling pathways in fibrosis of the heart
Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), remains an
unresolved problem in most forms of heart disease. In order to be successful in preventing …
unresolved problem in most forms of heart disease. In order to be successful in preventing …
Syndecan-4 signaling at a glance
A Elfenbein, M Simons - Journal of cell science, 2013 - journals.biologists.com
Syndecan-4, a ubiquitous cell surface proteoglycan, mediates numerous cellular processes
through signaling pathways that affect cellular proliferation, migration, mechanotransduction …
through signaling pathways that affect cellular proliferation, migration, mechanotransduction …
Cooperative coupling of cell-matrix and cell–cell adhesions in cardiac muscle
Adhesion between cardiac myocytes is essential for the heart to function as an
electromechanical syncytium. Although cell-matrix and cell–cell adhesions reorganize …
electromechanical syncytium. Although cell-matrix and cell–cell adhesions reorganize …
Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling
Atherosclerotic plaque localization correlates with regions of disturbed flow in which
endothelial cells (ECs) align poorly, whereas sustained laminar flow correlates with cell …
endothelial cells (ECs) align poorly, whereas sustained laminar flow correlates with cell …
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway
Extensive research over the past decades has identified integrins to be the primary
transmembrane receptors that enable cells to respond to external mechanical cues. We …
transmembrane receptors that enable cells to respond to external mechanical cues. We …