A cell constantly adapts to its environment. Cell decisions to survive, to proliferate or to
migrate are dictated not only by soluble growth factors, but also through the direct interaction …

Biophysical cues stemming from the extracellular environment are rapidly transduced into
discernible chemical messages (mechanotransduction) that direct cellular activities–placing …

Filopodia are adhesive cellular protrusions specialized in the detection of extracellular
matrix (ECM)-derived cues. Although ECM engagement at focal adhesions is known to …

For individual cells in tissues to create the diverse forms of biological organisms, it is
necessary that they must reliably sense and generate the correct forces over the correct …

Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix.
However, the mechanisms of integrin regulation in filopodia are poorly defined. Here, we …

Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability
through the integration of intermediate filaments (IFs) with cell junctions. Here, we …

Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for
controlling the unbridled growth of cells, thus preventing the formation of cancerous tissues …

p130Cas/BCAR1 is an adaptor protein devoid of any enzymatic or transcriptional activity,
whose modular structure with various binding motifs, allows the formation of multi-protein …

Cells have developed a unique set of molecular mechanisms that allows them to probe
mechanical properties of the surrounding environment. These systems are based on …

Src kinase plays an important role in a multitude of fundamental cellular processes and is
often found deregulated in tumors. Active Src adopts an open conformation, whereas …