Carbon/nitrogen homeostasis control in cyanobacteria

K Forchhammer, KA Selim - FEMS microbiology reviews, 2020 - academic.oup.com
ABSTRACT Carbon/nitrogen (C/N) balance sensing is a key requirement for the
maintenance of cellular homeostasis. Therefore, cyanobacteria have evolved a …

New views on PII signaling: from nitrogen sensing to global metabolic control

K Forchhammer, KA Selim, LF Huergo - Trends in Microbiology, 2022 - cell.com
PII proteins are multitasking information-processing proteins occurring in bacteria, archaea,
and plastids, decoding the metabolic state of the cells and providing this information to …

Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB

KA Selim, M Haffner, M Burkhardt, O Mantovani… - Science …, 2021 - science.org
Because of their photosynthesis-dependent lifestyle, cyanobacteria evolved sophisticated
regulatory mechanisms to adapt to oscillating day-night metabolic changes. How they …

PII-like signaling proteins: A new paradigm in orchestrating cellular homeostasis

KA Selim, V Alva - Current Opinion in Microbiology, 2024 - Elsevier
Members of the PII superfamily are versatile, multitasking signaling proteins ubiquitously
found in all domains of life. They adeptly monitor and synchronize the cell's carbon, nitrogen …

PII-like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response

KA Selim, F Haase, MD Hartmann… - Proceedings of the …, 2018 - pnas.org
Cyanobacteria are phototrophic prokaryotes that evolved oxygenic photosynthesis∼ 2.7
billion y ago and are presently responsible for∼ 10% of total global photosynthetic …

From cyanobacteria to Archaeplastida: new evolutionary insights into PII signalling in the plant kingdom

KA Selim, E Ermilova, K Forchhammer - New Phytologist, 2020 - Wiley Online Library
The PII superfamily consists of signal transduction proteins found in all domains of life.
Canonical PII proteins sense the cellular energy state through the competitive binding of …

The PII-NAGK-PipX-NtcA Regulatory Axis of Cyanobacteria: A Tale of Changing Partners, Allosteric Effectors and Non-covalent Interactions

A Forcada-Nadal, JL Llácer, A Contreras… - Frontiers in molecular …, 2018 - frontiersin.org
PII, a homotrimeric very ancient and highly widespread (bacteria, archaea, plants) key
sensor-transducer protein, conveys signals of abundance or poorness of carbon, energy …

Split NanoLuc technology allows quantitation of interactions between PII protein and its receptors with unprecedented sensitivity and reveals transient interactions

R Rozbeh, K Forchhammer - Scientific reports, 2021 - nature.com
PII proteins constitute a widespread signal transduction superfamily in the prokaryotic world.
The canonical PII signal proteins sense metabolic state of the cells by binding the metabolite …

Carbon signaling protein SbtB possesses atypical redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA

KA Selim, M Haffner, O Mantovani, R Albrecht… - Proceedings of the …, 2023 - pnas.org
The PII superfamily consists of widespread signal transduction proteins found in all domains
of life. In addition to canonical PII proteins involved in C/N sensing, structurally similar PII …