Since the human genome was sequenced, the term" epigenetics" is increasingly being
associated with the hope that we are more than just the sum of our genes. Might what we …

A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …

Overlap** epigenetic mechanisms have evolved in eukaryotic cells to silence the
expression and mobility of transposable elements (TEs). Owing to their ability to recruit the …

During the past decade, small non-coding RNAs have rapidly emerged as important
contributors to gene regulation. To carry out their biological functions, these small RNAs …

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and
the subsequent recruitment of chromodomain proteins such as heterochromatin protein …

Highlights•Unlike RNA decay, RNAi results in continued rounds of post-transcriptional
silencing.•Pathways exist for both uncleaved and small RNA-sliced transcripts to enter …

Transposons populate the landscape of all eukaryotic genomes. Often considered purely
genomic parasites, transposons can also benefit their hosts, playing roles in gene regulation …

Small RNA molecules of about 20–30 nucleotides have emerged as powerful regulators of
gene expression and genome stability. Studies in fission yeast and multicellular organisms …

In eukaryotes, small non-coding RNAs regulate gene expression, hel** to control cellular
metabolism, growth and differentiation, to maintain genome integrity, and to combat viruses …

Nuclear transcription is not restricted to genes but occurs throughout the intergenic and
noncoding space of eukaryotic genomes. The functional significance of this widespread …