[HTML][HTML] A high-resolution map of human RNA translation
Translated small open reading frames (smORFs) can have important regulatory roles and
encode microproteins, yet their genome-wide identification has been challenging. We …
encode microproteins, yet their genome-wide identification has been challenging. We …
Small open reading frames, how to find them and determine their function
Advances in genomics and molecular biology have revealed an abundance of small open
reading frames (sORFs) across all types of transcripts. While these sORFs are often …
reading frames (sORFs) across all types of transcripts. While these sORFs are often …
Single-cell RNA-seq-based proteogenomics identifies glioblastoma-specific transposable elements encoding HLA-I-presented peptides
We analyze transposable elements (TEs) in glioblastoma (GBM) patients using a
proteogenomic pipeline that combines single-cell transcriptomics, bulk RNA sequencing …
proteogenomic pipeline that combines single-cell transcriptomics, bulk RNA sequencing …
Protein-coding circular RNAs–mechanism, detection, and their role in cancer and neurodegenerative diseases
G Lindner, K Takenaka, K Santucci, Y Gao… - Biochemical and …, 2023 - Elsevier
Circular RNAs (circRNAs) are a unique class of non-coding RNAs and were originally
thought to have no protein-coding potential due to their lack of a 5′ cap and 3′ poly (A) …
thought to have no protein-coding potential due to their lack of a 5′ cap and 3′ poly (A) …
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer
Y Sugimoto, PJ Ratcliffe - Nature structural & molecular biology, 2022 - nature.com
Hypoxia inducible factor (HIF) and mammalian target of rapamycin (mTOR) pathways
orchestrate responses to oxygen and nutrient availability. These pathways are frequently …
orchestrate responses to oxygen and nutrient availability. These pathways are frequently …
The regulatory landscape of 5′ UTRs in translational control during zebrafish embryogenesis
The 5′ UTRs of mRNAs are critical for translation regulation during development, but their
in vivo regulatory features are poorly characterized. Here, we report the regulatory …
in vivo regulatory features are poorly characterized. Here, we report the regulatory …
De novo transcriptome assembly of mouse male germ cells reveals novel genes, stage-specific bidirectional promoter activity, and noncoding RNA expression
In mammals, the adult testis is the tissue with the highest diversity in gene expression. Much
of that diversity is attributed to germ cells, primarily meiotic spermatocytes and postmeiotic …
of that diversity is attributed to germ cells, primarily meiotic spermatocytes and postmeiotic …
Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics
Targeted protein degradation (TPD), as exemplified by proteolysis-targeting chimera
(PROTAC), is an emerging drug discovery platform. PROTAC molecules, which typically …
(PROTAC), is an emerging drug discovery platform. PROTAC molecules, which typically …
Conservation and selective pressures sha** baleen whale olfactory receptor genes supports their use of olfaction in the marine environment
AA Jauhal, R Constantine, R Newcomb - Molecular Ecology, 2024 - Wiley Online Library
The relative importance of various sensory modalities can shift in response to evolutionary
transitions, resulting in changes to underlying gene families encoding their reception …
transitions, resulting in changes to underlying gene families encoding their reception …
Pleiotropic effects of PAB1 deletion: Extensive changes in the yeast proteome, transcriptome, and translatome
Cytoplasmic poly (A)-binding protein (PABPC; Pab1 in yeast) is thought to be involved in
multiple steps of post-transcriptional control, including translation initiation, translation …
multiple steps of post-transcriptional control, including translation initiation, translation …