Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …

G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and
synthetic ligands, represent the largest family of druggable targets in the human genome …

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four
molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis …

Summary The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of
diverse genomic alterations underlying human cancers. At this historic junction marking the …

Uveal melanoma, a rare subset of melanoma, is the most common primary intraocular
malignancy in adults. Despite effective primary therapy, nearly 50% of patients will develop …

Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …

Melanoma is the most aggressive and dangerous form of skin cancer that develops from
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …

Most mutations in cancer are rare, which complicates the identification of therapeutically
significant mutations and thus limits the clinical impact of genomic profiling in patients with …

Uveal melanoma is an aggressive malignancy that originates from melanocytes in the eye.
Even if the primary tumor has been successfully treated with radiation or surgery, up to half …

Uveal melanoma (UM) is the most common intraocular malignancy and arises from
melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is …