Dual roles of supporting electrolytes in organic electrosynthesis

LG Gombos, J Nikl, SR Waldvogel - ChemElectroChem, 2024 - Wiley Online Library
Synthetic electro‐organic chemistry is advancing to a well‐established methodology in
academic research and industry. The simple process control minimizes reagent waste and …

Enhancing electrochemical reactions in organic synthesis: the impact of flow chemistry

M Regnier, C Vega, DI Ioannou, T Noël - Chemical Society Reviews, 2024 - pubs.rsc.org
Utilizing electrons directly offers significant potential for advancing organic synthesis by
facilitating novel reactivity and enhancing selectivity under mild conditions. As a result, an …

Overview of recent scale-ups in organic electrosynthesis (2000–2023)

D Lehnherr, L Chen - Organic Process Research & Development, 2024 - ACS Publications
This review summarizes examples of organic electrosynthesis from the peer-reviewed
literature from 2000 to 2023 that have been conducted on scales of 20 g or above. A …

[HTML][HTML] Recent advances in synthetic organic electrochemistry using flow systems

D Cantillo - Current Opinion in Electrochemistry, 2024 - Elsevier
The recent resurgence of electrochemical methods in organic synthesis has also boosted
the interest in the use of flow electrolysis cells. Flow electrolyzers are essential tools for the …

Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate

BK Malviya, EC Hansen, CJ Kong… - … Process Research & …, 2024 - ACS Publications
Electrochemical synthesis of a key thiol intermediate in the preparation of axitinib has been
achieved on a multi-10 g scale using a modified spinning cylinder electrode reactor adapted …

[HTML][HTML] Electrochemical Hofmann rearrangement at high current densities in a simple flow setup

DF Nater, P Hendriks, SR Waldvogel - Molecular Catalysis, 2024 - Elsevier
A reliable electrochemical version for the Hofmann rearrangement has been established,
which can be performed at high current density in simple, commercial flow electrolysis cells …

Design of Experiments-Based Optimization of an Electrochemical Decarboxylative Alkylation Using a Spinning Cylinder Electrode Reactor

N Petrović, GR Cumming, CA Hone… - … Process Research & …, 2024 - ACS Publications
A design of experiments model has been developed to optimize an electrochemical protocol
for the decarboxylative N-alkylation of pyrazole in a spinning cylinder electrode reactor. The …

Scalable Electrochemical Dehalogenative Carboxylation without a Sacrificial Metal Anode

N Petrovic, G Laudadio, CA Salazar… - Advanced Synthesis …, 2025 - Wiley Online Library
A scalable electrochemical procedure for the synthesis of carboxylic acids from organic
halides has been developed using a spinning cylinder electrode electrochemical reactor …

Adoption of Electrochemistry within the Pharmaceutical Industry: Insights from an Industry-Wide Survey

AC Ferretti, B Cohen, L Deng, M Diwan… - … Process Research & …, 2025 - ACS Publications
This article presents the results of a comprehensive survey on the adoption of
electrochemistry among 17 major pharmaceutical companies. The study examined key …

Scalable catalyst free electrochemical chlorination of aminophenol derivatives enabled by a quasi-divided cell approach

BK Malviya, G Laudadio, CO Kappe, D Cantillo - Green Chemistry, 2024 - pubs.rsc.org
Chlorinated 4-aminophenol derivatives are widespread in pharmaceutical ingredients. An
electrochemical procedure for the synthesis of these compounds via mono-and …