C–H functionalization has been emerging as a powerful method to establish carbon–carbon
and carbon–heteroatom bonds. Many efforts have been devoted to transition-metal …

The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

In 1994, Ye and McKervey published a paper in Chemical Reviews entitled “Organic
Synthesis with α-Diazocarbonyl Compounds”. 1 Our intention then was to draw attention to …

The palladium-catalyzed cross-coupling reaction between organoboron compounds and
organic halides or triflates provides a powerful and general methodology for the formation of …

1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

Since the discovery of organic azides by Peter Grieß more than 140 years ago, numerous
syntheses of these energy‐rich molecules have been developed. In more recent times in …

Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes,
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …

The effective use of ring strain has been applied to considerable advantage for the
construction of complex systems. The focus here is directed towards cyclopropanes as …

Novel reactions that can selectively functionalize carbon–hydrogen bonds are of intense
interest to the chemical community because they offer new strategic approaches for …

From its earliest observation as an unusual reaction only a half century ago, 1 the insertion
of a carbene into a carbonrhydrogen bond has attracted considerable interest because of its …