Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …

Excitotoxicity may play a role in certain disorders of the motor system thought to be caused
by environmentally acquired toxins, including lathyrism and domoic acid poisoning. Motor …

Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis
(ALS). Here, through a combination of RNA-Seq and electrophysiological studies on …

The reason for the selective vulnerability of motor neurons in amyotrophic lateral sclerosis
(ALS) is primarily unknown. A possible factor is the expression by motor neurons of Ca2+ …

The “glutamate hypothesis” is one of three major pathophysiological mechanisms of motor
neurone injury towards which current research effort into amyotrophic lateral sclerosis (ALS) …

We employed a mouse model of ALS, in which overexpression of a familial ALS-linked
Cu/Zn–SOD mutation leads to progressive MN loss and a clinical phenotype remarkably …

The effects of oxidative stress within post mitotic cells such as neurones may be cumulative,
and injury by free radical species is a major potential cause of the age‐related deterioration …

The cause of the selective degeneration of motor neurons in amyotrophic lateral sclerosis
(ALS) remains unexplained. One potential pathogenetic mechanism is chronic toxicity due to …

The causes of motor neuron death in amyotrophic lateral sclerosis (ALS) are so far
unknown. The involvement of mitochondria in the disease was initially suggested by …

Excessive excitation is hypothesized to cause motoneuron (MN) degeneration in
amyotrophic lateral sclerosis (ALS), but actual proof of hyperexcitation in vivo is missing, and …