Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma

T Sasahira, T Kirita - International journal of molecular sciences, 2018‏ - mdpi.com
Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading
malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little …

[HTML][HTML] STAT3 and its targeting inhibitors in oral squamous cell carcinoma

M Jiang, B Li - Cells, 2022‏ - mdpi.com
Oral squamous cell carcinoma (OSCC) usually originates from the precancerous lesions of
oral mucosa and accounts for approximately 90% of oral cancers. Current therapeutic …

The prognostic role of PD-L1 expression for survival in head and neck squamous cell carcinoma: A systematic review and meta-analysis

W Yang, MCM Wong, PJ Thomson, KY Li, Y Su - Oral oncology, 2018‏ - Elsevier
Background Programmed death-ligand 1 (PD-L1) is an immune checkpoint that is primarily
located on the surface of tumor cells. PD-L1 expression detected by immunohistochemistry …

Increased expression of PD-1 and PD-L1 in oral lesions progressing to oral squamous cell carcinoma: a pilot study

K Dave, A Ali, M Magalhaes - Scientific Reports, 2020‏ - nature.com
Oral cancer is a devastating disease and is commonly preceded by a range of oral
premalignant disorders. We investigated the expression of PD-1 and PD-L1 in oral epithelial …

Progress in targeted therapeutic drugs for oral squamous cell carcinoma

L Liu, J Chen, X Cai, Z Yao, J Huang - Surgical oncology, 2019‏ - Elsevier
With the rapid development of biomedicine, people have a deeper understanding with the
biological characteristics of malignant tumors, and begin to notice that in most tumors, there …

Integrative molecular characterization of resistance to neoadjuvant chemoradiation in rectal cancer

SC Kamran, JK Lennerz, CA Margolis, D Liu… - Clinical Cancer …, 2019‏ - aacrjournals.org
Purpose: Molecular properties associated with complete response or acquired resistance to
concurrent chemotherapy and radiotherapy (CRT) are incompletely characterized …

[HTML][HTML] Immune checkpoint inhibitors in oral cavity squamous cell carcinoma and oral potentially malignant disorders: a systematic review

O Kujan, B van Schaijik, CS Farah - Cancers, 2020‏ - mdpi.com
Cancers of the oral cavity cause significant cancer-related death worldwide. While survival
rates have improved in recent years, new methods of treatment are being investigated to …

Prognostic and clinicopathological significance of PD-L1 overexpression in oral squamous cell carcinoma: A systematic review and comprehensive meta-analysis

D Lenouvel, MÁ González-Moles, I Ruiz-Avila… - Oral oncology, 2020‏ - Elsevier
Abstract Background The presence of Programmed Death-Ligand 1 protein (PD-L1) in oral
squamous cell carcinoma (OSCC) may indicate an ability to evade immune response and …

Crosstalk between PD-L1 and Jak2-Stat3/MAPK-AP1 signaling promotes oral cancer progression, invasion and therapy resistance

A Jha, M Alam, T Kashyap, N Nath, A Kumari… - International …, 2023‏ - Elsevier
Background Programmed cell death ligand-1 (PD-L1) is an antitumor immunity molecule
and a great target to cure oral cancer; nonetheless, the limited success can be attributed to …

PD-L1 expression in tumor cells is an independent unfavorable prognostic factor in oral squamous cell carcinoma

JC de Vicente, T Rodríguez-Santamarta… - Cancer Epidemiology …, 2019‏ - aacrjournals.org
Background: The immune checkpoint PD-1 and its ligand PD-L1 are involved in the
induction of immunological tolerance of solid tumors including oral squamous cell …