Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

In recent years, lipid metabolism has garnered significant attention as it provides the
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …

Background De novo lipogenesis (DNL) is a complex and highly regulated metabolic
pathway. In normal conditions DNL converts excess carbohydrate into fatty acids that are …

Thyroid hormones have widespread cellular effects; however it is unclear whether their
effects on the central nervous system (CNS) contribute to global energy balance. Here we …

Peroxisome proliferator–activated receptors (PPARs) regulate energy metabolism and
hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non …

Fatty acid synthase (FASN) is a key enzyme involved in neoplastic lipogenesis.
Overexpression of FASN is common in many cancers, and accumulating evidence suggests …

Mechanisms controlling the proliferative activity of neural stem and progenitor cells (NSPCs)
have a pivotal role to ensure life-long neurogenesis in the mammalian brain. How metabolic …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

The nuclear receptor PPARα is activated by drugs to treat human disorders of lipid
metabolism. Its endogenous ligand is unknown. PPARα-dependent gene expression is …