Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …

Melatonin, N‐acetyl‐5‐methoxytryptamine, an evolutionally old molecule, is produced by the
pineal gland in vertebrates, and it binds with high affinity to melatonin receptors, which are …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

The pineal hormone melatonin has attracted great scientific interest since its discovery in
1958. Despite the enormous number of basic and clinical studies the exact role of melatonin …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

Alzheimer's disease (AD) is a chronic, progressive and prevalent neurodegenerative
disease characterized by the loss of higher cognitive functions and an associated loss of …

Nowadays, melatonin, previously considered only as a pharmaceutical product for rhythm
regulation and sleep aiding, has shown its potential as a co‐adjuvant treatment in intestinal …

Besides its well‐known regulatory role on circadian rhythm, the pineal gland hormone
melatonin has other biological functions and a distinct metabolism in various cell types and …

Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …

Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal
gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and …