Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain.
In the past, there has been a major research drive focused on the dysfunction of the …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to
be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short …

Although it is evident from the literature that altered GABA B receptor function does affect
behavior, these results often do not correspond well. These differences could be due to the …

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

The hippocampus, in the temporal lobe, is phylogenetically one of the oldest parts of the
brain and forms part of the limbic system. The hippocampus proper is defined by the dentate …

Amyloid β (Aβ) is thought to play an important role in the pathogenesis of Alzheimer's
disease. Aβ may exert its neurotoxic effects via multiple mechanisms and in particular …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …

The G-protein-gated inwardly rectifying potassium (Kir3/GIRK) channel is the effector of
many G-protein-coupled receptors (GPCRs). Its dysfunction has been linked to the …