Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …

Mass cytometry (cytometry by time-of-flight detection [CyTOF]) is a bioanalytical technique
that enables the identification and quantification of diverse features of cellular systems with …

The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

Since their discovery over 100years ago, bisphosphonates have been used industrially as
corrosion inhibitors and complexing agents. With the discovery of their pharmacological …

The combination of radionuclide-based imaging modalities such as single photon emission
computed tomography (SPECT) and positron emission tomography (PET) with magnetic …

This review provides a summary of the coordination chemistry of mono-, bis-and
polyphosphonates, as well as of their functionalized analogues. Specific interactions with …

There are several isotopes of copper and rhenium that are of interest in the development of
new molecular imaging or radiotherapeutic agents. This perspective article highlights the …

Poly (ethylene glycol)(PEG) is the most popular polymer for protein conjugation, but its
potential as carrier of low molecular weight drugs has been limited by the intrinsic low …

Introduction: Bisphosphonates (BPs) were introduced 45 years ago as anti-osteoporotic
drugs and during the last decade have been utilized as bone-targeting groups in systemic …