Linking Aβ and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
Alzheimer's disease is characterized by abnormal elevation of Aβ peptide and abnormal
hyperphosphorylation of the tau protein. The" amyloid hypothesis," which is based on …
hyperphosphorylation of the tau protein. The" amyloid hypothesis," which is based on …
Phenotypic correlations in FTDP-17
LA Reed, ZK Wszolek, M Hutton - Neurobiology of aging, 2001 - Elsevier
Frontotemporal dementias with parkinsonism linked to chromosome 17 (FTDP-17) are
hereditary tauopathies affecting at least 50 known kindred worldwide. Most kindred present …
hereditary tauopathies affecting at least 50 known kindred worldwide. Most kindred present …
Phenotypic variation in hereditary frontotemporal dementia with tau mutations
JC Van Swieten, M Stevens, SM Rosso… - Annals of Neurology …, 1999 - Wiley Online Library
Several mutations in the tau gene have been found in families with hereditary frontotemporal
dementia and parkinsonism linked to chromosome 17q21‐22 (FTDP‐17). This study is the …
dementia and parkinsonism linked to chromosome 17q21‐22 (FTDP‐17). This study is the …
Clinical features of frontotemporal dementia due to the intronic tau 10+16 mutation
JC Janssen, EK Warrington, HR Morris, P Lantos… - Neurology, 2002 - AAN Enterprises
Objective: To describe the clinical features of nine British families with neuropathologically
verified frontotemporal dementia (FTD) due to the intronic tau exon 10+ 16 mutation …
verified frontotemporal dementia (FTD) due to the intronic tau exon 10+ 16 mutation …
[HTML][HTML] Multiple system atrophy: genetic risks and alpha-synuclein mutations
Multiple system atrophy (MSA) is one of the few neurodegenerative disorders where we
have a significant understanding of the clinical and pathological manifestations but where …
have a significant understanding of the clinical and pathological manifestations but where …
Frontotemporal dementia—a brief review
M Sjögren, C Andersen - Mechanisms of ageing and development, 2006 - Elsevier
Frontotemporal dementia (FTD) is the second most common type of presenile dementia and
the forth most common type of senile dementia, but probably the most costly due to its florid …
the forth most common type of senile dementia, but probably the most costly due to its florid …
Frontotemporal dementia and parkinsonism linked to chromosome 17
B Ghetti, ZK Wszolek, BF Boeve… - … of dementia and …, 2011 - Wiley Online Library
This chapter describes the various aspects of frontotemporal dementia and parkinsonism
linked to chromosome 17 (FTDP‐17) associated with mutations in the microtubule …
linked to chromosome 17 (FTDP‐17) associated with mutations in the microtubule …
The apolipoprotein E ε4 allele selectively increases the risk of frontotemporal lobar degeneration in males
Objective: To determine whether polymorphic variations in the apolipoprotein E gene
(APOE) are associated with increased risk of frontotemporal lobar degeneration (FTLD) …
(APOE) are associated with increased risk of frontotemporal lobar degeneration (FTLD) …
Apolipoprotein E ϵ4 Allele Has No Effect on Age at Onset or Duration of Disease in Cases of Frontotemporal Dementia with Pick-or Microvacuolar-Type Histology
Frontotemporal dementia (FTD) is the second most common cause of presenile dementia.
Here we have investigated the frequency of the ϵ4 allele of the Apolipoprotein (APOE) gene …
Here we have investigated the frequency of the ϵ4 allele of the Apolipoprotein (APOE) gene …
Apolipoprotein E polymorphism in German patients with frontotemporal degeneration
M Riemenschneider, J Diehl, U Müller… - Journal of Neurology …, 2002 - jnnp.bmj.com
Objectives: The apolipoprotein E (apoE) polymorphism, designated as ε2, ε3, ε4, is a genetic
risk factor associated with several forms of dementia. Inconclusive results have been …
risk factor associated with several forms of dementia. Inconclusive results have been …