The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …

Cell membranes are composed of a lipid bilayer, containing proteins that span the bilayer
and/or interact with the lipids on either side of the two leaflets. Although recent advances in …

During T cell activation, the transmembrane adaptor protein LAT (linker for activation of T
cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has …

Cell membranes display a tremendous complexity of lipids and proteins designed to perform
the functions cells require. To coordinate these functions, the membrane is able to laterally …

Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …

Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …

The physical basis for protein partitioning into lipid rafts remains an outstanding question in
membrane biology that has previously been addressed only through indirect techniques …

To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …

The membrane raft hypothesis postulates the existence of lipid bilayer membrane
heterogeneities, or domains, supposed to be important for cellular function, including lateral …

Membrane lateral heterogeneity is accepted as a requirement for the function of biological
membranes and the notion of lipid rafts gives specificity to this broad concept. However, the …