Role of inactivity in chronic diseases: evolutionary insight and pathophysiological mechanisms

FW Booth, CK Roberts, JP Thyfault… - Physiological …, 2017 - journals.physiology.org
This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

Blood flow restriction training and the high-performance athlete: science to application

C Pignanelli, D Christiansen… - Journal of Applied …, 2021 - journals.physiology.org
The manipulation of blood flow in conjunction with skeletal muscle contraction has greatly
informed the physiological understanding of muscle fatigue, blood pressure reflexes, and …

Under the hood: skeletal muscle determinants of endurance performance

S van Der Zwaard, F Brocherie… - Frontiers in sports and …, 2021 - frontiersin.org
In the past decades, researchers have extensively studied (elite) athletes' physiological
responses to understand how to maximize their endurance performance. In endurance …

Research into the health benefits of sprint interval training should focus on protocols with fewer and shorter sprints

NBJ Vollaard, RS Metcalfe - Sports medicine, 2017 - Springer
Over the past decade, it has been convincingly shown that regularly performing repeated
brief supramaximal cycle sprints (sprint interval training [SIT]) is associated with aerobic …

Contribution of oxygen extraction fraction to maximal oxygen uptake in healthy young men

Ø Skattebo, JAL Calbet, B Rud, C Capelli… - Acta …, 2020 - Wiley Online Library
We analysed the importance of systemic and peripheral arteriovenous O2 difference
(difference and a‐vfO2 difference, respectively) and O2 extraction fraction for maximal …

The influence of skeletal muscle mitochondria and sex on critical torque and performance fatiguability in humans

RM McDougall, TR Tripp, BP Frankish… - The Journal of …, 2023 - Wiley Online Library
Critical torque (CT) represents the highest oxidative steady state for intermittent knee
extensor exercise, but the extent to which it is influenced by skeletal muscle mitochondria …

Lifelong Endurance Exercise as a Countermeasure Against Age-Related Decline: Physiological Overview and Insights from Masters Athletes

PL Valenzuela, NA Maffiuletti, MJ Joyner, A Lucia… - Sports Medicine, 2020 - Springer
Maximum oxygen consumption (̇ VO _ 2 max V˙ O 2 max) is not only an indicator of
endurance performance, but also a strong predictor of cardiovascular disease and mortality …

Endurance exercise training changes the limitation on muscle V ̇ O 2 max ̇V_O_2max in normoxia from the capacity to utilize O2 to the capacity to transport O2

RM Broxterman, PD Wagner… - The Journal of …, 2024 - Wiley Online Library
Abstract Maximal oxygen (O2) uptake (V ̇ O 2 max ̇V_O_2max) is an important parameter
with utility in health and disease. However, the relative importance of O2 transport and …

Maximal oxygen uptake is proportional to muscle fiber oxidative capacity, from chronic heart failure patients to professional cyclists

S van der Zwaard, CJ de Ruiter… - Journal of Applied …, 2016 - journals.physiology.org
V̇o2 max during whole body exercise is presumably constrained by oxygen delivery to
mitochondria rather than by mitochondria's ability to consume oxygen. Humans and animals …

NIRS-derived skeletal muscle oxidative capacity is correlated with aerobic fitness and independent of sex

AT Beever, TR Tripp, J Zhang… - Journal of Applied …, 2020 - journals.physiology.org
Near-infrared spectroscopy (NIRS) provides a simple and reliable measure of skeletal
muscle oxidative capacity; however, its relationship to aerobic fitness and sex are unclear …