The FGF/FGFR system in breast cancer: oncogenic features and therapeutic perspectives

MF Santolla, M Maggiolini - Cancers, 2020 - mdpi.com
Simple Summary The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR)
system represents an emerging therapeutic target in breast cancer. Here, we discussed …

OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2

Q Zhu, Y Fu, CP Cui, Y Ding, Z Deng, C Ning… - Signal transduction and …, 2023 - nature.com
Bone homeostasis is maintained by the balance between osteoblastic bone formation and
osteoclastic bone resorption. Dysregulation of this process leads to multiple diseases …

The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein

X Liu, L Rao, A Gennerich - Nature communications, 2020 - nature.com
Cytoplasmic dynein is the primary motor for microtubule minus-end-directed transport and is
indispensable to eukaryotic cells. Although each motor domain of dynein contains three …

[HTML][HTML] N-Acetyl-d-Glucosamine Kinase Interacts with NudC and Lis1 in Dynein Motor Complex and Promotes Cell Migration

MA Islam, HJ Choi, R Dash, SR Sharif… - International Journal of …, 2020 - mdpi.com
Recently, we showed that N-acetylglucosamine kinase (NAGK), an enzyme of amino sugar
metabolism, interacts with dynein light chain roadblock type 1 (DYNLRB1) and promotes the …

Role of NDEL1 and VEGF/VEGFR-2 in mouse hippocampus after status epilepticus

L Zhu, S Dai, D Lu, P Xu, L Chen, Y Han… - ASN …, 2020 - journals.sagepub.com
Nuclear-distribution element-like 1 (NDEL1) is associated with the proliferation and
migration of neurons. Vascular endothelial growth factor (VEGF) in combination with VEGF …

A perturbation proteomics-based foundation model for virtual cell construction

R Sun, L Qian, Y Li, H Cheng, Z Xue, X Zhang, L Tan… - bioRxiv, 2025 - biorxiv.org
Building a virtual cell requires comprehensive understanding of protein network dynamics of
a cell which necessitates large-scale perturbation proteome data and intelligent …

The role of DISC1 in the organization of the T-cell immunological synapse

NA Maskalenko - 2019 - repositories.lib.utexas.edu
When T-cells contact an antigenic target or antigen-presenting cell, signaling through the T-
cell receptor triggers formation of a specialized junction known as the immunological …