Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays
a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic …

SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

The first line of host defense against infectious agents involves activation of innate immune
signaling pathways that recognize specific pathogen-associated molecular patterns …

African swine fever virus (ASFV) is a complex, cytoplasmic double-stranded DNA (dsDNA)
virus that is currently expanding throughout the world. Currently, circulating virulent …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

The interferon (IFN) system is one of the first lines of defense activated against invading viral
pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of …

Colorectal cancer is one of the most common causes of mortality worldwide. There are
several potential risk factors responsible for the initiation and progression of colorectal …

Oncolytic viruses (OVs), viruses engineered to lyse tumor cells, work hand in hand with the
immune response. While for decades the field isolated lytic capability and viral spread to …