The biofilm life cycle: expanding the conceptual model of biofilm formation

K Sauer, P Stoodley, DM Goeres… - Nature Reviews …, 2022 - nature.com
Bacterial biofilms are often defined as communities of surface-attached bacteria and are
typically depicted with a classic mushroom-shaped structure characteristic of Pseudomonas …

Biofilms: Formation, drug resistance and alternatives to conventional approaches

R Mirghani, T Saba, H Khaliq, J Mitchell… - AIMS …, 2022 - pmc.ncbi.nlm.nih.gov
Biofilms are aggregates of bacteria, in most cases, which are resistant usually to broad-
spectrum antibiotics in their typical concentrations or even in higher doses. A trend of …

Chronic inflammation in non-healing skin wounds and promising natural bioactive compounds treatment

P Schilrreff, U Alexiev - International journal of molecular sciences, 2022 - mdpi.com
Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to
immune regulation. The dysregulation of the immune system leads to continuing …

Antibiotics versus biofilm: an emerging battleground in microbial communities

D Sharma, L Misba, AU Khan - Antimicrobial Resistance & Infection …, 2019 - Springer
Biofilm is a complex structure of microbiome having different bacterial colonies or single type
of cells in a group; adhere to the surface. These cells are embedded in extracellular …

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

O Ciofu, T Tolker-Nielsen - Frontiers in microbiology, 2019 - frontiersin.org
Pseudomonas aeruginosa is one of the six bacterial pathogens, Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis

P Chakraborty, S Bajeli, D Kaushal, BD Radotra… - Nature …, 2021 - nature.com
Tuberculosis is a chronic disease that displays several features commonly associated with
biofilm-associated infections: immune system evasion, antibiotic treatment failures, and …

Persistent bacterial infections and persister cells

RA Fisher, B Gollan, S Helaine - Nature Reviews Microbiology, 2017 - nature.com
Many bacteria can infect and persist inside their hosts for long periods of time. This can be
due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective …

Gram positive and Gram negative bacteria differ in their sensitivity to cold plasma

A Mai-Prochnow, M Clauson, J Hong, AB Murphy - Scientific reports, 2016 - nature.com
Cold atmospheric-pressure plasma (CAP) is a relatively new method being investigated for
antimicrobial activity. However, the exact mode of action is still being explored. Here we …

Biofilm-related disease

JL Del Pozo - Expert review of anti-infective therapy, 2018 - Taylor & Francis
Introduction: Biofilm formation represents a protected mode of growth that renders bacterial
cells less susceptible to antimicrobials and to killing by host immune effector mechanisms …

Therapeutic strategies against biofilm infections

S Mishra, A Gupta, V Upadhye, SC Singh, RP Sinha… - Life, 2023 - mdpi.com
A biofilm is an aggregation of surface-associated microbial cells that is confined in an
extracellular polymeric substance (EPS) matrix. Infections caused by microbes that form …