Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates

S Nagini, M Palrasu, A Bishayee - Medicinal research reviews, 2024 - Wiley Online Library
Abstract Neem (Azadirachta indica A. Juss.), a versatile evergreen tree recognized for its
ethnopharmacological value, is a rich source of limonoids of the triterpenoid class, endowed …

Development of potential antitumor agents from the scaffolds of plant-derived terpenoid lactones

Y Ren, AD Kinghorn - Journal of medicinal chemistry, 2020 - ACS Publications
Naturally occurring terpenoid lactones and their synthetic derivatives have attracted
increasing interest for their promising antitumor activity and potential utilization in the …

Multilayer capsules encapsulating nimbin and doxorubicin for cancer chemo-photothermal therapy

V Sharma, J Vijay, MR Ganesh… - International Journal of …, 2020 - Elsevier
Abstract Layer-by-layer (LbL) assembled poly (allylamine hydrochloride)(PAH) and poly
(methacrylic acid)(PMA) microcapsules were designed to incorporate gold nanorods (NRs) …

Epoxyazadiradione induced apoptosis/anoikis in triple‐negative breast cancer cells, MDA‐MB‐231, by modulating diverse cellular effects

S Lakshmi, J Renjitha, SB Sasidhar… - Journal of Biochemical …, 2021 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is one of the most aggressive forms of its kind, which
accounts for 15–20% of all breast cancers. As this cancer form lacks hormone receptors …

Bioactivity assays, chemical characterization, ADMET predictions and network analysis of Khaya senegalensis A. Juss (Meliaceae) extracts

M de la Luz Cádiz-Gurrea, KI Sinan, G Zengin… - Food Research …, 2021 - Elsevier
Abstract Khaya senegalensis A. Juss (Meliaceae) is a popular medicinal plant, widely used
in the management of various ailments in the African traditional medicine. This study …

Limonoids isolated from fruits of Swietenia macrophylla king enhance glucose consumption in insulin‐resistant HepG2 cells via activating PPARγ

JY Duan, YJ Wang, W Chen, YQ Zhao… - Journal of Food …, 2021 - Wiley Online Library
The fruits of Swietenia macrophylla King have been processed commercially to a variety of
health foods and healthcare products and exhibited antidiabetic, anti‐inflammatory …

Trichilones A–E: New Limonoids from Trichilia adolfi

M Gonzalez-Ramirez, I Limachi, S Manner, JC Ticona… - Molecules, 2021 - mdpi.com
In addition to the trichilianones A–D recently reported from Trichilia adolfi, a continuing
investigation of the chemical constituents of the ethanol extract of the bark of this medicinal …

Azadiradione (AZD) neem biomass derived limonoid: extraction, characterization, and potential biological activities with special reference to anti-microbial and anti …

PS Priya, RS Kumar, MRA Gawwad, KM Alarjani… - South African Journal of …, 2023 - Elsevier
The resistance of conventional drugs to bacterial infections and cancer poses a significant
threat to the healthcare system causing increased mortality. Metabolites derived from plant …

Trichilianones AD, Novel Cyclopropane-Type Limonoids from Trichilia adolfi

I Limachi, M Gonzalez-Ramirez, S Manner, JC Ticona… - Molecules, 2021 - mdpi.com
The fractionation of an ethanol extract of the bark of Trichilia adolfi yielded four novel
limonoids (trichilinones AD, 1–4), with five fused rings and related to the hortiolide-type …

Dysobinol Extracted from Chisocheton Macrophyllus Triggers Proliferation Inhibition, Potential Apoptosis, and Cell Cycle Arrest of He La Cancer Cell Lines

S Gaffar, E Hafiz, H Lina Wiraswat, S Ishmayana… - 2024 - repository.unar.ac.id
Dysobinol is a new limonoid from C. macrophyllus seeds reported to have an anticancer
activity. This study aimed to determine the cytotoxic activity of Dysobinol against HeLa …