BACKGROUND A worldwide increase in the prevalence of obesity has been observed in the
past three decades, particularly in women of reproductive age. Female obesity has been …

Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the
body weight by balancing food intake and energy expenditure. However, this adipocyte …

BACKGROUND The embryo implantation process is crucial for the correct establishment
and progress of pregnancy. During implantation, the blastocyst trophectoderm cells attach to …

The understanding of adipose tissue role has evolved from that of a depot energy storage
organ to a dynamic endocrine organ. While genetics, sexual phenotype and sex steroids …

Liver fibrosis can progress to cirrhosis, which is considered a serious disease. The Child-
Pugh score and the model of end-stage liver disease score have been established to assess …

The dramatic increase in the prevalence of obesity coincides with a decline in reproductive
health indices in both sexes. Energy excess mediates changes to the regulatory …

In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …

The prevalence of obesity in adults worldwide, and specifically in women of reproductive
age, is concerning given the risks to fertility posed by the increased risk of type 2 diabetes …

Background Leptin may have important implications in polycystic ovary syndrome (PCOS)-
related metabolic disorders. However, the changes in serum leptin levels in patients with …

Polycystic ovary syndrome (PCOS) affects approximately 15% of women of reproductive age
worldwide. It is the most prevalent endocrine disorder with marked risks for female infertility …