Designing improved active peptides for therapeutic approaches against infectious diseases
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …
few decades, pathogenic microorganisms' resistance to conventional drugs has been …
Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets
Containment of the COVID-19 pandemic requires reducing viral transmission. Severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by membrane fusion …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by membrane fusion …
Measles encephalitis: towards new therapeutics
Measles remains a major cause of morbidity and mortality worldwide among vaccine
preventable diseases. Recent decline in vaccination coverage resulted in re-emergence of …
preventable diseases. Recent decline in vaccination coverage resulted in re-emergence of …
Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain
The emergence of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the
etiological agent of the 2019 coronavirus disease (COVID-19), has erupted into a global …
etiological agent of the 2019 coronavirus disease (COVID-19), has erupted into a global …
Measles virus fusion protein: structure, function and inhibition
P Plattet, L Alves, M Herren, HC Aguilar - Viruses, 2016 - mdpi.com
Measles virus (MeV), a highly contagious member of the Paramyxoviridae family, causes
measles in humans. The Paramyxoviridae family of negative single-stranded enveloped …
measles in humans. The Paramyxoviridae family of negative single-stranded enveloped …
New insights into measles virus brain infections
S Watanabe, Y Shirogane, Y Sato, T Hashiguchi… - Trends in …, 2019 - cell.com
Measles virus (MeV) may persist in the brain, causing fatal neurodegenerative diseases,
subacute sclerosing panencephalitis, and measles inclusion-body encephalitis. However …
subacute sclerosing panencephalitis, and measles inclusion-body encephalitis. However …
Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity
S Mougari, V Favède, C Predella, O Reynard… - Communications …, 2025 - nature.com
We have assessed antiviral activity and induction of protective immunity of fusion-inhibitory
lipopeptides derived from the C-terminal heptad-repeat domain of SARS-CoV-2 spike …
lipopeptides derived from the C-terminal heptad-repeat domain of SARS-CoV-2 spike …
Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections
Peptides and peptide-based materials have an increasing role in the treatment of viral
infections through their use as active pharmaceutical ingredients, targeting moieties …
infections through their use as active pharmaceutical ingredients, targeting moieties …
Activation of cGAS/STING pathway upon paramyxovirus infection
During inflammatory diseases, cancer, and infection, the cGAS/STING pathway is known to
recognize foreign or self-DNA in the cytosol and activate an innate immune response. Here …
recognize foreign or self-DNA in the cytosol and activate an innate immune response. Here …
Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain
Measles virus (MeV) bearing a single amino acid change in the fusion protein (F)—L454W—
was isolated from two patients who died of MeV central nervous system (CNS) infection. This …
was isolated from two patients who died of MeV central nervous system (CNS) infection. This …