Metformin: update on mechanisms of action and repurposing potential

M Foretz, B Guigas, B Viollet - Nature Reviews Endocrinology, 2023 - nature.com
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

[HTML][HTML] Atherosclerosis: recent developments

JLM Björkegren, AJ Lusis - Cell, 2022 - cell.com
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …

RNA modifications: importance in immune cell biology and related diseases

L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Atherosclerosis: Known and unknown

J Fan, T Watanabe - Pathology international, 2022 - Wiley Online Library
Atherosclerotic disease, such as myocardial infarction and stroke, is the number one killer
worldwide. Atherosclerosis is considered to be caused by multiple factors, including genetic …

Atherosclerosis and inflammation: Insights from the theory of general pathological processes

E Gusev, A Sarapultsev - International Journal of Molecular Sciences, 2023 - mdpi.com
Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism

S Qiao, C Liu, L Sun, T Wang, H Dai, K Wang… - Nature …, 2022 - nature.com
Obesity, dyslipidemia and gut dysbiosis are all linked to cardiovascular diseases. A
Ganoderma meroterpene derivative (GMD) has been shown to alleviate obesity and …

Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis

M Gao, M Tang, W Ho, Y Teng, Q Chen, L Bu, X Xu… - ACS …, 2023 - ACS Publications
Atherosclerosis is a common pathology present in many cardiovascular diseases. Although
the current therapies (including statins and inhibitors of the serine protease PCSK9) can …

A bibliometric analysis of T cell and atherosclerosis

N Wei, Y Xu, Y Li, J Shi, X Zhang, Y You… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis (AS) is widespread and develops into circulatory system problems. T cells
play an essential regulatory role in AS occurrence and development. So far, there is no …