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Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
Unlocking the secrets: Volatile Organic Compounds (VOCs) and their devastating effects on lung cancer
MS Hussain, G Gupta, R Mishra, N Patel… - … -Research and Practice, 2024 - Elsevier
Lung cancer (LCs) is still a serious health problem globally, with many incidences attributed
to environmental triggers such as Volatile Organic Compounds (VOCs). VOCs are a broad …
to environmental triggers such as Volatile Organic Compounds (VOCs). VOCs are a broad …
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
Y Oka, Y Nakazawa, M Shimada, T Ogi - Nature Cell Biology, 2024 - nature.com
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and
require repair by multiple pathways. Whether transcription blockage contributes to the …
require repair by multiple pathways. Whether transcription blockage contributes to the …
A genetic map of the response to DNA damage in human cells
M Olivieri, T Cho, A Álvarez-Quilón, K Li… - Cell, 2020 - cell.com
The response to DNA damage is critical for cellular homeostasis, tumor suppression,
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …
Fanconi anemia: current insights regarding epidemiology, cancer, and DNA repair
JD Peake, E Noguchi - Human genetics, 2022 - Springer
Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …
as a predisposition to malignancies including leukemia and squamous cell carcinoma …
Fanconi anaemia and cancer: an intricate relationship
G Nalepa, DW Clapp - Nature Reviews Cancer, 2018 - nature.com
Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
L Mulderrig, JI Garaycoechea, ZK Tuong, CL Millington… - Nature, 2021 - nature.com
Endogenous DNA damage can perturb transcription, triggering a multifaceted cellular
response that repairs the damage, degrades RNA polymerase II and shuts down global …
response that repairs the damage, degrades RNA polymerase II and shuts down global …
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
G Burgos-Barragan, N Wit, J Meiser, FA Dingler… - Nature, 2017 - nature.com
The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables
the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might …
the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might …
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism
VN Pham, KJ Bruemmer, JDW Toh, EJ Ge, L Tenney… - Science, 2023 - science.org
One-carbon metabolism is an essential branch of cellular metabolism that intersects with
epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit …
epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit …