Multiple factors combined are currently recognized as contributors to cognitive decline. The
main independent risk factor for cognitive impairment and dementia is advanced age …

Alzheimer's disease (AD) is a pressing global issue, demanding effective diagnostic
approaches. This systematic review surveys the recent literature (2018 onwards) to …

The circadian clock modulates human physiology. However, the organization of tissue-
specific gene expression rhythms and how these depend on age and sex is not defined in …

The accumulation of irreparable cellular damage restricts healthspan after acute stress or
natural aging. Senescent cells are thought to impair tissue function, and their genetic …

Background Projections of future mortality and life expectancy are needed to plan for health
and social services and pensions. Our aim was to forecast national age-specific mortality …

Since the desire for real-time human health monitoring as well as seamless human-machine
interaction is increasing rapidly, plenty of research efforts have been made to investigate …

One of the leading causes of morbidity and premature mortality in older people is frailty.
Frailty occurs when multiple physiological systems decline, to the extent that an individual's …

Background The oldest-old (those aged≥ 80 years) are the most rapidly growing age group
globally, and are most in need of health care and assistance. We aimed to assess changes …

Objective To examine the association between risk factor burdens—categorized as optimal,
borderline, or elevated—and the lifetime risk of atrial fibrillation. Design Community based …

Driven by technological progress, human life expectancy has increased greatly since the
nineteenth century. Demographic evidence has revealed an ongoing reduction in old-age …