The role of oxidative stress in the pathogenesis of infections with coronaviruses

C Gain, S Song, T Angtuaco, S Satta… - Frontiers in …, 2023‏ - frontiersin.org
Coronaviruses can cause serious respiratory tract infections and may also impact other end
organs such as the central nervous system, the lung and the heart. The coronavirus disease …

The efficacy of multivitamin, vitamin A, vitamin B, vitamin C, and vitamin D supplements in the prevention and management of COVID-19 and long-COVID: an updated …

A Sinopoli, A Sciurti, C Isonne, MM Santoro… - Nutrients, 2024‏ - mdpi.com
This review aims to evaluate the efficacy of any vitamin administration (s) in preventing and
managing COVID-19 and/or long-COVID. Databases were searched up to May 2023 to …

Intravenous vitamin C for patients hospitalized with COVID-19: two harmonized randomized clinical trials

S Florescu, D Stanciu, M Zaharia, A Kosa, D Codreanu… - Jama, 2023‏ - jamanetwork.com
Importance The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.
Objective To determine whether vitamin C improves outcomes for patients with COVID-19 …

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

AS Naidu, CK Wang, P Rao, F Mancini… - npj Science of …, 2024‏ - nature.com
Abstract SARS‐CoV‐2, the etiological agent of COVID-19, is devoid of any metabolic
capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic …

Lessons we learned during the past four challenging years in the COVID-19 era: pharmacotherapy, long COVID complications, and vaccine development

P Ghasemiyeh, S Mohammadi-Samani - Virology Journal, 2024‏ - Springer
About four years have passed since the detection of the first cases of COVID-19 in China.
During this lethal pandemic, millions of people have lost their lives around the world. Since …

Impact of intravenous vitamin C as a monotherapy on mortality risk in critically ill patients: a meta-analysis of randomized controlled trials with trial sequential analysis

KC Hung, MH Chuang, JY Chen, CW Hsu… - Frontiers in …, 2023‏ - frontiersin.org
Background This meta-analysis aimed at investigating the pooled evidence regarding the
effects of intravenous vitamin C (IVVC) on mortality rate in critically ill patients. Methods …

Association of oral or intravenous vitamin C supplementation with mortality: a systematic review and meta-analysis

C Xu, T Yi, S Tan, H Xu, Y Hu, J Ma, J Xu - Nutrients, 2023‏ - mdpi.com
Mortality is the most clinically serious outcome, and its prevention remains a constant
struggle. This study was to assess whether intravenous or oral vitamin C (Vit-C) therapy is …

Ascorbic acid modulates immune responses through Jumonji‐C domain containing histone demethylases and Ten eleven translocation (TET) methylcytosine …

J Maity, S Majumder, R Pal, B Saha… - …, 2023‏ - Wiley Online Library
Ascorbic acid is a redox regulator in many physiological processes. Besides its antioxidant
activity, many intriguing functions of ascorbic acid in the expression of immunoregulatory …

Nutrition and immunity: lessons from coronavirus disease-2019

PC Calder - Proceedings of the Nutrition Society, 2023‏ - cambridge.org
This review will provide an overview of the immune system and then describe the effects of
frailty, obesity, specific micronutrients and the gut microbiota on immunity and susceptibility …

Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments

C Loucera, R Carmona, M Esteban-Medina… - Virology Journal, 2023‏ - Springer
Purpose Despite the extensive vaccination campaigns in many countries, COVID-19 is still a
major worldwide health problem because of its associated morbidity and mortality …