Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong
risk factor for the development of type 2 diabetes mellitus. Insulin resistance in the setting of …

The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …

Lipoproteins and Atherosclerosis Christopher K. Glass*†‡ and Joseph L. Witztum*
Specialized Center of Research on Molecular Serum cholesterol is carried by several …

B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

vasodilator capacity. 22 In addition to producing vasodilatation, nitric oxide can impair
platelet aggregation. Nitric oxide also has a direct anti-inflammatory effect, augmenting …

Dietary fat intake is an environmental factor that affects many aspects of human health. 1
Several lines of evidence suggest that common diseases of modern society are associated …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

Previous work has implicated PPARγ in the regulation of CD36 expression and macrophage
uptake of oxidized LDL (oxLDL). We provide evidence here that in addition to lipid uptake …