Recent findings indicate that WD40 domains play central roles in biological processes by
acting as hubs in cellular networks; however, they have been studied less intensely than …

Our knowledge of the large family of proteins that contain the WD repeat continues to
accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a …

Abstract The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-
aspartate repeat (WD-repeat) family of proteins and shares significant homology to the β …

WD-repeat proteins are regulatory beta-propeller platforms that enable the assembly of
multiprotein complexes. Here, we report the functional and bioinformatic analysis of human …

Heterotrimeric G proteins in vertebrates constitute a family molecular switches that transduce
the activation of a populous group of cell-surface receptors to a group of diverse effector …

The Drosophila Groucho (Gro) protein is the prototype for a large family of corepressors,
examples of which are found in most metazoans. This family includes the human transducin …

Vesicle and tubule transport containers move proteins and lipids from one membrane
system to another. Newly forming transport containers frequently have electron-dense coats …

Gle2p is implicated in nuclear export of poly (A)+ RNA and nuclear pore complex (NPC)
structure and distribution in Saccharomyces cerevisiae. Gle2p is anchored at the nuclear …

Publisher Summary This chapter discusses the cyclic nucleotide phosphodiesterases
(PDE4) cyclic Adenosine monophosphate (cAMP)-specific phosphodiesterases. Inhibitors …

Centrins are calmodulin-like proteins present in microtubule-organizing centers. The
Saccharomyces cerevisiae centrin, Cdc31p, was functionally tagged with a single Z domain …